2012 Fiscal Year Final Research Report
Study for post-operative adjuvant therapy choice by using autoantibodies in patients with breast cancer
| Project/Area Number |
23701100
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Clinical oncology
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
TAMESA Michiko 山口大学, 医学部付属病院, 医師 (10570822)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 乳癌 / 自己抗体 / プロテオミクス / 二次元電気泳動 |
|---|
| Research Abstract |
Protein samples from breast cancer tissues and paired non-cancerous tissues were analyzed by two-dimensional gel electrophoresis. After reaction with sera from patients with breast cancer or cancer-free patients, 10 spots which reacted to auto-antibodies from patients with breast cancer and not reacted to control sera were detected. Mass spectrometry analysis by LC-MS/MS identified three spots such as peptidyl-prolyl cis-trans isomerase A, but the other spots were not identified. Further studies for identifying the other spots are expectable.
|
