2012 Fiscal Year Final Research Report
Search for antitumor compounds from symbiotic or parasitic microbes in aquatic multicellular organisms
| Project/Area Number |
23701108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
WADA Shun-ichi 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 (40450233)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 抗がん物質探索 / ケミカルバイオロジー |
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| Research Abstract |
In this study, the researcher aimed for efficient searching of new antitumor agents. About 1000 strains of microbes were isolated from aquatic organisms and cultured. Cytotoxic compounds against cancer cells were isolated from the metabolites. While 13 known compounds were identified, 8 compounds were estimated as novel compounds. The researcher established the evaluation and comparison system of cytotoxicity employing multiple culture cell lines. Harnessing the system, a novel compound lentztrehalose was discovered and a protein phosphatase 2A specific inhibitor rubratoxin A was launched as a molecular probe.
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