X-ray induced autophagy in radioresistant cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 23710066
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tohoku University
• Principal Investigator: KUWAHARA Yoshikazu 東北大学, 加齢医学研究所, 助教 (00392225)
• Project Period (FY): 2011 – 2012
• Keywords: 放射線耐性 / 活性酸素種

Research Abstract

Efficient removal of reactive oxygen species from cytoplasm of clinically relevant radioresistant cells leads to low incidence of autophagic cell death of those cells after X-ray exposure.

Research Products

• [Journal Article] Distribution of artificial radionuclides in abandoned cattle in theeva cuation zone of the Fukushima Daiichi nuclear power plant (2013)
  • Author(s): Fukuda T, Kino Y, Abe Y, Yamashiro H, Kuwahara Y, Nihei H, Sano Y, Irisawa A, Shimura T, Fukumoto M, Shinoda H, Obata Y, Saigusa S, Sekine T, Isogai E, Fukumoto M.
  • Journal Title: PLoS One Volume: 8(1) Pages: e54312
  • DOI: doi:10.1371/journal.pone.0054312.
  • Peer Reviewed
• [Journal Article] Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes (2012)
  • Author(s): Kobayashi T, Saito Y, Ohtake Y, Maruko A, Yamamoto Y, Yamamoto F, Kuwahara Y, Fukumoto M, Fukumoto M, Ohkubo Y.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 3(7) Pages: G861-9
  • DOI: doi:10.1152/ajpgi.00081.2012.
  • Peer Reviewed
• [Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells (2012)
  • Author(s): Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, Takahashi A, Fukumoto M.
  • Journal Title: Oncogenesis Volume: 1 Pages: e12
  • DOI: doi:10.1038/oncsis.2012.12.
  • Peer Reviewed
• [Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy (2011)
  • Author(s): Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar MH, Fukumoto M, Shimura T, Ohtake Y, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M.
  • Journal Title: Cell Death Dis Volume: 2 Pages: e177
  • DOI: doi:10.1038/cddis.2011.56.
  • Peer Reviewed
• [Presentation] 被災家畜における放射性物質の動態及びと畜前推定技術の検証 (2013)
  • Author(s): 山城秀昭、阿部靖之、福田智一、木野康志、桑原義和、福本基、小林仁、篠田壽、関根勉、磯貝恵美子、福本学
  • Organizer: 放射性物質汚染と食の安全-被災地の畜産業復興を願って-
  • Place of Presentation: 東京
  • Year and Date: 2013-03-16
• [Presentation] 臨床的放射線耐性細胞がなぜドセタキセルに耐性を示すのか? (2012)
  • Author(s): 桑原義和、福本基、福本学
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] 臨床的放射線耐性細胞がなぜドセタキセルに耐性を示すのか? (2012)
  • Author(s): 桑原義和、福本基、福本学
  • Organizer: 日本放射線影響学会第55回大会
  • Place of Presentation: 仙台
  • Year and Date: 20120906-08
• [Presentation] 臨床的放射線耐性細胞はなぜドセタキセルに耐性を示すのか? (2012)
  • Author(s): 桑原義和、福本基、福本学
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20120426-28