2013 Fiscal Year Final Research Report
Phenotypic and genotypic features of radiation-induced mammary cancer and insights into its cell of origin
| Project/Area Number |
23710074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
IMAOKA Tatsuhiko 独立行政法人放射線医学総合研究所, 放射線防護研究センター, チームリーダー (40356134)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生物影響 / 放射線発がん / in vivo実験 / 起源細胞 / 乳がん / 単回照射 |
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| Research Abstract |
It is unclear whether radiation-induced breast cancer shows specific phenotypic and genotypic features and originates from cells at a specific differentiation stage. We evaluated the associations between genetic and phenotypic features of spontaneous, radiation-induced and chemically-induced rat mammary cancers. We revealed that clustering analyses of immunohistochemical and microarray-based gene expression profile data classified the cancers into several subtypes. Radiation-induced cancers were overrepresented in a specific subtype, which developed earlier than others. As this subtype has been reported to originate from a specific progenitor cell in humans and mice, the present results suggest that radiation-induced rat mammary cancer initiates in cells at a specific differentiation stage.
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[Journal Article] Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma2013
Author(s)
Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Toshiaki Kokubo, Kazutaka Doi, Daisuke Iizuka, Yukiko Nishimura, Tomomi Okutani, Masaru Takabatake, Shizuko Kakinuma, Yoshiya Shimada
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 85(4)
Pages: 1134-1140
DOI
Peer Reviewed
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[Presentation] Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions2011
Author(s)
Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Daisuke Iizuka, Toshiaki Kokubo, Yukiko Nishimura, Tomomi Okutani, Masaru Takabatake, Shizuko Kakinuma, Takashi Takabatake, Yi Shang, Yoshiya Shimada
Organizer
14th International Congress of Radiation Research
Place of Presentation
Warsaw
Year and Date
20110800
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