2013 Fiscal Year Final Research Report
Preparation of functional hydrogels composed of filamentous viruses
| Project/Area Number |
23710122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Tokyo Institute of Technology (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
SAWADA Toshiki 東京工業大学, 理工学研究科, 助教 (20581078)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体関連高分子科学 / 生物有機化学 / ソフトマテリアル / バイオテクノロジー |
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| Research Abstract |
For the preparation of functional hydrogels composed of filamentous viruses, genetically engineered M13 bacteriophages (phages) and surface-modified gold nanoparticles (GNPs) were utilized. After mixing of the components under the suitable concentration condition, the mixed solutions were self-assembled into hydrogels. The phages and the GNPs in the hydrogels formed lyotropic liquid crystals and well-ordered fractal like network structures, respectively. Furthermore, it was found that mechanical strengths of the viral hydrogels were dependent on the specific molecular interactions between the phages and the GNPs. Furthermore, the hydrogels showed various functions such as self-repairing capabilities and responsiveness for existence of Escherichia coli.
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