Functionalized Conducting Polymer Nanostructures for Enhanced Capturing and Monitoring of Circulating Tumor Cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 23710138
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: LUO Shyh Chyang 独立行政法人理化学研究所, Yu 独立主幹研究ユニット, 基幹研究所研究員 (70565051)
• Project Period (FY): 2011 – 2012
• Keywords: 循環腫瘍細胞を捕捉 / 導電性ポリマー / ナノ構造 / スマート・マテリアル

Research Abstract

During these two years, we have accomplished several tasks, including synthesis of functionalized conducting polymers for bioconjugation, the fabrication of conducting polymer nanostructures and the protocol design of circulating tumor cells (CTC) capturing. For nanostructure fabrication, we demonstrated both template and template-free methods. We observed that the capture efficiency was enhanced by 4 - 5 times comparing to smooth films. We also developed a cell capture and release platform using polymer-grafted silicon nanostructures as the platform.

Research Products

• [Journal Article] Molecular or Nanoscale Structures? The Deciding Factor of Surface Properties on Functionalized Poly(3,4-ethylenedioxythiophene) Nanorod Arrays (2013)
  • Author(s): Lin, H. -A.; Luo, Shyh-Chyang; Zhu, B.; Chen, C.; Yamashita, Y.; Yu, H. -h
  • Volume: (Published Online)
  • DOI: DOI:10.1002/adfm.201203006
  • Peer Reviewed
• [Journal Article] Capture and Stimulated Release of Circulating Tumor Cells on Polymer Grafted Silicon Nanostructures (2013)
  • Author(s): Hou, S.; Zhao, H.; Zhao, L.; Shen, Q.; Wei, K. S.; Suh, D. Y.; Nakao, A.; Garcia, M. A.; Song, M.; Lee, T; Xiong, B.; Luo, Shyh-Chyang; Tseng, H. -R.; Yu, H. -h
  • Journal Title: Advanced Materials Volume: 25 Pages: 1547-1551
  • Peer Reviewed
• [Journal Article] Polydioxythiophene Nanodots, Nanowires, Nano-Networks, and Tubular Structures: The Effect of Functional Groups and Temperature in Template-Free Electropolymerization (2012)
  • Author(s): Luo, Shyh-Chyang; Sekine, J.; Zhu, B.; Zhao, H.; Nakao, A.; Yu, H. -h
  • Journal Title: ACS Nano Volume: 6 Pages: 3018-3026
• [Journal Article] Tunable, Dynamic and Electrically Stimulated Lectin-Carbohydrate Recognition on a Glycan-Grafted Conjugated Polymer (2012)
  • Author(s): Luo, Shyh-Chyang; Kantchev, E. A. B.; Zhu, B.; Siang, Y. W.; Yu, H. -h
  • Journal Title: Chemical Communication Volume: 48 Pages: 6942-6944
  • Peer Reviewed
• [Journal Article] Functionalized Conducting Polymer Nanodots for Enhanced Cell Capturing : the Synergistic Effect of Capture Agents and Nanostructures (2011)
  • Author(s): Sekine, J.; Luo, Shyh-Chyang; Zhu, B.; Wang, S. T.; Tseng H. -R.; Yu, H.-h
  • Journal Title: Advanced Materials Volume: 46 Pages: 4788-4792
  • Peer Reviewed
• [Presentation] The Formation of Nanostructure of Functionalized Polydioxythiophene by Template-free Electropolymerization and Its Biomedical Application (2013)
  • Author(s): Luo, Shyh-Chyang, Sekine, J.; Zhu, B.; Zhao, H.; Nakao, A.; Yu, H. -h
  • Organizer: Molecular Materials Meeting (M3)
  • Place of Presentation: Biopolis, Singapore
  • Year and Date: 20130114-16
• [Presentation] Tunable, Dynamic and Electrically Stimulated Lectin-Carbohydrate Recognition on a Glycan-Grafted Conjugated Polymer (2012)
  • Author(s): Luo, Shyh-Chyang, Zhu, B., Siang, Y. W., Kantchev, E. A. B., Yu, H. -h
  • Organizer: International Conference on Bioinspired and Biobased Chemistry & Materials
  • Place of Presentation: Nice, France
  • Year and Date: 20120803-05
• [Presentation] Tunable and Dynamic Lectin-Carbohydrate Recognition on the Surface of Conducting Polymer-bound Glycan Mimic Substrates (2012)
  • Author(s): Luo, Shyh-Chyang, Zhu, B., Kantchev, E. A. B., Yu, H. -h
  • Organizer: 61th Society of Polymer Science, Japan
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20120529-31
• [Presentation] Nanostructured PEDOT Biointerfaces for Enhanced Efficiency of Cell Capturing (2011)
  • Author(s): Luo, Shyh-Chyang, Sekine, J., Zhu, B., Yu, H. -h
  • Organizer: International Union of Materials Research Societies- 12th International Conference in Asia
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20110919-22
• [Presentation] Nanostructured PEDOT Thin Films by Electropolymerization- Understanding Structure and Temperature Effect (2011)
  • Author(s): Luo, Shyh-Chyang, Zhu, B., Sekine, J., Zhao, H. C., Yu, H. -h
  • Organizer: 60th Society of Polymer Science, Japan
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20110525-27