2012 Fiscal Year Final Research Report
Formation of Size-controlled Giant Unilamellar Liposomes
| Project/Area Number |
23710154
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Microdevices/Nanodevices
|
|---|
| Research Institution | 公益財団法人神奈川科学技術アカデミー (2012)
Kanagawa Academy of Science and Technology (2011) |
|---|
Principal Investigator |
OSAKI Toshihisa 公益財団法人神奈川科学技術アカデミー, バイオマイクロシステムプロジェクト, 研究員 (50533650)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 脂質 / 生体材料(リポソーム) / 人工細胞膜 / マイクロアレイ |
|---|
| Research Abstract |
In this study, we developed a method that allows formation of a uniform-size giant unilamellar liposome array. Microfabrication technologies and an electrospray technique enabled precise patterning of lipids on a substrate; with a simple hydration process of the lipid pattern, we succeeded in highly reproducible giant liposome array formation with a narrow range of size distribution. The formed liposomes were well suitable for model cell membrane studies. We further developed manipulation devices for the liposomes based on dielectrophoresis phenomena.
|
