2012 Fiscal Year Final Research Report
Functional Involvement of Tudor in the piRNA Processing Pathway in Drosophila Germlines
| Project/Area Number |
23710219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | piRNA生合成 / PIWIタンパク質 / TUDORドメインタンパク質 / 生殖細胞 |
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| Research Abstract |
We discovered that immunopurified BmTud complexes from BmN4 contain BmSpn-E and Siwi. Depletion of BmSpn-E also caused Siwi to be loaded with less piRNAs than that in naive BmN4 cells. We discovered that Siwi, in a form associated with BmSpn-E, is not sig
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