2012 Fiscal Year Final Research Report
Transcription regulation by Transcription factors and Epigenetic factors
| Project/Area Number |
23710224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 疾患エピゲノミクス |
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| Research Abstract |
Human genome has over 20,000 genes. Transcription factors and epigenetic factors including histone modifiers, are pivotal factors for gene expression.Mutation in these genes causes congenital heart diseases. But it was still unclear which genes are regulated by these transcription factors. Here, we identified these transcription factors-binding genomic regions using next-generation sequencer, and the target genes that are regulated by these factors.
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[Journal Article] PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia.2011
Author(s)
Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kaneda Y.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 108(16)
Pages: 6609-14
DOI
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