2013 Fiscal Year Final Research Report

Functional analysis of ulcerative colitis susceptibility genes and implementation for clinical practice

Research Project

Project/Area Number	23710225
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Medical genome science
Research Institution	Kyushu University
Principal Investigator	ASANO Kouichi 九州大学, 大学病院, 助教 (40593893)
Project Period (FY)	2011 – 2013
Keywords	疾患関連遺伝子 / 潰瘍性大腸炎 / 遺伝子発現解析 / 予後予測
Research Abstract	We have previousely identified ulcerative colitis (UC), an intractable disease, susceptibility genes, and we aimed to investigate further precise pathogenesis of the disease and to analyse effects of UC susceptibility genes on the clinical course. Analyses of UC susceptibility genes revealed that a copy numver variation region exist at FCGR3A gene and that allele copy number of FCGR3A located in this CNV region is associated with UC susceptibility. Next, we investigated effect of UC susceptibility genes on the relapse status of the disease. As a result, SNPs at FCGR2A gene and 13q region were associated with the risk of relapse of the disease. Thus, UC susceptibility genes revealed to not only play a role in the pathogenesis of the disease, but also have effects of the clinical course.

(2 results)