2012 Fiscal Year Final Research Report
The method for reconstructing chromosomal conformation through informatics
| Project/Area Number |
23710230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ゲノム情報学 / ChIP-seq 法 / データ可視化 |
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| Research Abstract |
We have developed a cost-effective and time-efficient program DROMPA for ChIP-seq analysis. DROMPA can visualize a protein-binding map, which can reduce the total cost for an analysis. By using DROMPA, we comprehensively investigated the cohesin binding sites for human B-cells. We found that a part of cohesin sites colocalize with an enhancer marker with tissue-specific manner, and such sites were lost for CdLS, that is caused by the loss of cohesin function.
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Research Products
(10 results)
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[Journal Article] Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast2012
Author(s)
Tazumi A., Fukuura M., Nakato R., Kishimoto A., Takenaka T., Ogawa S.,Song J.H., Takahashi T.S., Nakagawa T., Shirahige K., Masukata H.
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Journal Title
Genes Dev
Volume: 26
Pages: 2050-2062
Peer Reviewed
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[Journal Article] Replisome stability at defective DNA replication forks is independent of S-phase checkpoint kinases2012
Author(s)
De Piccoli, G., Katou, Y., Itoh, T., Nakato, R., Shirahige, K., and Labib, K.
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Journal Title
Molecular Cell
Volume: 45
Pages: 696-704
Peer Reviewed
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