2013 Fiscal Year Final Research Report
Integrative modeling of genetic interactions based on intertwined multi-level networks
| Project/Area Number |
23710233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 多階層ネットワーク / 分子間相互作用 / 遺伝子 / 発現制御 |
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| Research Abstract |
Genes had been considered to be factors that can be analyzed individually, and their effect on functions and phenotypes can be modeled linearly. However, now they are rather considered as non-linearly interacting entities to other genes and other types of biomolecules whose roles and control would be more complicated and context-dependent than we thought. This research regards genes as building blocks of intertwined multi-level networks of various biomolecules, and develops computational methods for integratively analyzing behaviors thorough the networks and for relating quantitative measurements of individual building blocks to the known structures of corresponding networks. Recent studies are producing large data such as transcriptomes, metabolomes, proteomes, and fluxomes, and many databases on biological networks are being developed. The integrative computational approaches thus need to be established to leverage these rich data on various networks and their constituents.
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