2013 Fiscal Year Final Research Report
A systems approach to elucidate gene regulatory network for gernline development and fertility
| Project/Area Number |
23710237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SATO Masanao 基礎生物学研究所, 発生遺伝学研究部門, 助教 (20517693)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 発生 / 生殖細胞 / 不妊 |
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| Research Abstract |
The signaling network in a germline cell was modeled using BmN4, the cell line derived from a Bombyx mori ovary. The network model is composed of genes that are evolutionarily conserved between B. mori and Drosophila melanogaster and that have been known as regulators for signal transduction in D. melanogaster germline or somatic cell development. The model suggested a gene known as a regulator of germline development in D. melanogaster as a hub in the network. In addition, the model inferred roles of genes of which mutations caused sterility by unknown reasons. Furthermore, the model inferred roles of genes, which have been known to function in somatic cells, in germline cells.
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