2012 Fiscal Year Final Research Report
Exploration of Innate Immune Regulators from Unexploited Microorganisms
| Project/Area Number |
23710247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 天然物化学 / 自然免疫 / 二次代謝産物 / 生物活性物質 / 未利用微生物 |
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| Research Abstract |
To screen pharmaceuticals that target innate immunity, we established an ex vivo culture system based on the innate immune response of Drosophila, which is highly useful for identifying immune regulators that act on human innate immunity. We used this system to search for natural substances that regulate innate immunity, and identified terresterol and TM-DIF-1 as an activator and a suppressor, respectively. In addition, we synthesized gonytolide A, aspergillicin F and their derivatives.
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Research Products
(13 results)
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[Journal Article] The Structures of the Dimeric and Monomeric Chromanones, Gonytolides A-C, Isolated from the Fungus Gonytrichum sp. and Their Promoting Activities of Innate Immune Responses2011
Author(s)
Kikuchi, H.; Isobe, M.; Sekiya, M.; Abe, Y.; Hoshikawa, T.; Ueda, K.; Kurata, S.; Katou, Y.; Oshima, Y
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Journal Title
Org. Lett
Volume: 13
Pages: 4624-4627
DOI
Peer Reviewed
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