2012 Fiscal Year Final Research Report
Production of novel fungal secondary metabolites by epigenetically activating the silent biosynthetic gene clusters.
| Project/Area Number |
23710248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 天然物 / 二次代謝物 / 糸状菌 / 二次代謝制御 / エピジェネティクス / ヒストン脱 アセチル化酵素 / 酵素阻害剤 |
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| Research Abstract |
In this study, we found some effective conditions for activating fungal secondary metabolism by using epigenetic modifiers such as HADC and DNA methyltransferase inhibitors. Using the conditions, we successfully isolated structurally diverse novel fungal secondary metabolites from cryptic biosynthetic pathways, showing the utility to enlarge chemical space composed of natural products. In addition, we obtained the evidence that over expression of LaeA, an epigenetic enzyme, in fungi is possible way to enhance their production of secondary metabolites.
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Research Products
(27 results)
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[Journal Article] An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii2013
Author(s)
Y. M. Chung, C. K. Wei, D. W. Chuang, M. E. Shazly, C. T. Hsieh, T. Asai, Y. Oshima, T. J. Hsieh, T. L. Hwang, Y. C. Wu, F. R. Chang
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Journal Title
Bioorg. Med. Chem
Volume: 21
Pages: 3866-3872
DOI
Peer Reviewed
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[Journal Article] Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers2012
Author(s)
T. Asai, Y. M. Chung, H. Sakurai, T. Ozeki, F. R.Chang, K. Yamashita, Y, Oshima
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Journal Title
Org. Lett
Volume: 14
Pages: 513-515
DOI
Peer Reviewed
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