2012 Fiscal Year Final Research Report
Development of selective phosphatase inhibitor based on calyculin A
| Project/Area Number |
23710250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | カリクリン / タンパク質脱リン酸化酵素 / チョコガタイシカイメン |
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| Research Abstract |
Many marine natural products exhibit highly potent cytotoxicity. They selectively inhibit the functions of either intracellular or membrane-bound target molecules, leading to cell death. These specific biological activities can provide valuable information on the biochemical research field. Therefore, we initiated this program aimed at the development of functionalized calyculin A, a protein phosphatase inhibitor, which was originally isolated from the marine sponge, Discodermia calyx. Based on the insights into the structural moieties essential for biological activity, the synthetic process toward library construction and fluorescent probe were developed.
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