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2013 Fiscal Year Final Research Report

Evaluation of inflammatory bowel disease by metabolomics and identification of the therapeutic molecule candidates

Research Project

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Project/Area Number 23710256
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Living organism molecular science
Research InstitutionKobe University

Principal Investigator

NISHIUMI Shin  神戸大学, 医学(系)研究科(研究院), 特命講師 (20514706)

Project Period (FY) 2011 – 2013
Keywords炎症性腸疾患 / メタボロミクス
Research Abstract

The aim of this study was to elucidate whether the pathogenesis of inflammatory bowel disease leads to alterations in the levels of low molecular weight metabolites by using metabolomics. As a result, the experiments using colon of sodium dextran sulfate-induced colitis mice, IL10 deficient colitis mice and ulcerative colitis patients found that the level of glutamine in the colon was decreased by the pathogenesis of inflammatory bowel disease. In addition, it was also confirmed that disease activity of ulcerative colitis could be evaluated by metabolite alterations.

  • Research Products

    (6 results)

All 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis2011

    • Author(s)
      Ooi M., Nishiumi S., Yoshie T., Shiomi Y., Kohashi M., Fukunaga K., Nakamura S., Matsumoto T., Hatano N., Shinohara M., Irino Y., Takenawa T., Azuma T., Yoshida M.
    • Journal Title

      Inflammation Research

      Volume: 60 Pages: 831-840

    • Peer Reviewed
  • [Journal Article] A novel gas chromatography mass spectrometry-based serum diagnostic and assessment approach to ulcerative colitis

    • Author(s)
      Kohashi M., Nishiumi S., Ooi M., Yoshie T., Matsubara A., Suzuki M., Hoshi N., Kamikozuru K., Yokoyama Y., Fukunaga K., Nakamura S., Azuma T., Yoshida M.
    • Journal Title

      Journal of Crohn's & colitis

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] メタボロミクスの消化器疾患診断・治療への応用2014

    • Author(s)
      西海信
    • Organizer
      日本薬学会第134年会シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      20140327-30
  • [Presentation] メタボロミクスの消化器疾患への応用2013

    • Author(s)
      西海信
    • Organizer
      第3回日本質量分析学会春季シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2013-06-20
  • [Presentation] メタボロミクスを用いた炎症性疾患に対する新規治療薬の探索への試み2012

    • Author(s)
      西海信、和泉自泰、松原惇起、東健、吉田優
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      愛知
    • Year and Date
      20121025-26
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/gi/index.html

URL: 

Published: 2015-06-25  

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