2013 Fiscal Year Final Research Report
Evaluation of inflammatory bowel disease by metabolomics and identification of the therapeutic molecule candidates
| Project/Area Number |
23710256
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Kobe University |
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Principal Investigator |
NISHIUMI Shin 神戸大学, 医学(系)研究科(研究院), 特命講師 (20514706)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 炎症性腸疾患 / メタボロミクス |
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| Research Abstract |
The aim of this study was to elucidate whether the pathogenesis of inflammatory bowel disease leads to alterations in the levels of low molecular weight metabolites by using metabolomics. As a result, the experiments using colon of sodium dextran sulfate-induced colitis mice, IL10 deficient colitis mice and ulcerative colitis patients found that the level of glutamine in the colon was decreased by the pathogenesis of inflammatory bowel disease. In addition, it was also confirmed that disease activity of ulcerative colitis could be evaluated by metabolite alterations.
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Research Products
(6 results)
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[Journal Article] GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis2011
Author(s)
Ooi M., Nishiumi S., Yoshie T., Shiomi Y., Kohashi M., Fukunaga K., Nakamura S., Matsumoto T., Hatano N., Shinohara M., Irino Y., Takenawa T., Azuma T., Yoshida M.
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Journal Title
Inflammation Research
Volume: 60
Pages: 831-840
Peer Reviewed
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[Journal Article] A novel gas chromatography mass spectrometry-based serum diagnostic and assessment approach to ulcerative colitis
Author(s)
Kohashi M., Nishiumi S., Ooi M., Yoshie T., Matsubara A., Suzuki M., Hoshi N., Kamikozuru K., Yokoyama Y., Fukunaga K., Nakamura S., Azuma T., Yoshida M.
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Journal Title
Journal of Crohn's & colitis
Volume: (in press)
Peer Reviewed
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