2012 Fiscal Year Final Research Report
Library Synthesis of Destruxin E and its Biological Evaluation
| Project/Area Number |
23710264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | V-ATPase / 環状ペプチド / ライブラリー / 構造活性相関 |
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| Research Abstract |
Library synthesis of destruxin E utilizing solid-phase synthesis has been achieved. Parallel synthesis of the cyclization precursors was performed by solid-phase peptide synthesis. After cleavage from the polymer-support, MNBA-mediated macrolactonization in solution-phase, followed by the epoxide formation furnished destruxin E library containing side chain- or ring size-modified derivatives.
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