2012 Fiscal Year Final Research Report
Biosynthetic mechanism of the wobble modified uridines in tRNA
| Project/Area Number |
23710265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUZUKI Takeo 東京大学, 大学院・工学系研究科, 講師 (90533125)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞内化学反応 / tRNA / 転写後修飾 / ミトコンドリア |
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| Research Abstract |
We investigated two human gene products, hGTPBP3 and hMTO1, which modify the wobble uridine of human mitochondrial tRNAs. They localized in mitochondria and interacted each other. Replacement of each of these genes from yeast homologues to human genes did not complement modification activity, and the C-terminal region of hGTPBP3 was suggested to be required for the wobble modification.
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Research Products
(11 results)
