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2013 Fiscal Year Final Research Report

Effect of Ethereal Oxygens on the Biological Activities of Ladder-Shaped Polyethers

Research Project

  • PDF
Project/Area Number 23710274
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical biology
Research InstitutionKyushu University

Principal Investigator

TORIKAI Kohei  九州大学, 理学(系)研究科(研究院), 助教 (20456990)

Project Period (FY) 2011 – 2013
Keywordsバイオプローブ / 梯子状ポリエーテル / 海産毒 / 活性発現機構
Research Abstract

Ladder-shaped polyethers are mainly marine toxins produced by dinoflagellates. The objective of this research was to clarify how the ladder-shaped polyethers work in our bodies to exert their toxicity.
In the synthetic studies of natural products, basic parts (building blocks) are first synthesized and a target molecule will be built up using these parts. However, in this research, we faced difficulties in synthesizing a large quantity of parts by traditional methods. Therefore, novel recipe was established to supply enough building blocks successfully. This result will drastically accelerate the building-up works, being challenged all over the world.

  • Research Products

    (8 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Synthesis and Biological Activity of the C'D'E'F' Ring System of Maitotoxin2014

    • Author(s)
      Kunitake, M.; Oshima, T.; Konoki, K.; Ebine, M.; Torikai, K.; Murata, M.; Oishi, T.
    • Journal Title

      J. Org. Chem.

      Volume: (in press)

    • DOI

      10.1021/jo5005235

    • Peer Reviewed
  • [Journal Article] A Facile and Practical Synthesis of Nicolaou's Key Intermediates, 2-Methyl-and 2,6-Dimethyl-Tetrahydropyrans, toward the Total Synthesis of Ladder-Shaped Polyethers2013

    • Author(s)
      Nakashima, T.; Baba, T.; Onoue, H.; Yamashita, W.; Torikai, K.
    • Journal Title

      Synthesis

      Volume: 45 Pages: 2417-2425

    • DOI

      10.1055/s-0033-1338503

    • Peer Reviewed
  • [Presentation] 梯子状ポリエーテル類の合成に有用なテトラヒドロピラン誘導体の実用的合成2013

    • Author(s)
      鳥飼浩平・中嶋勇晴・馬場萌未・尾上久晃・山下航
    • Organizer
      統合物質創製化学推進事業第4回若手研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-06-28
  • [Presentation] Design and Synthesis of Artificial Compounds; A Natural Product-Driven Research2013

    • Author(s)
      Kohei Torikai
    • Organizer
      Special Seminar in Pharmaceutical Sciences, Walailak University -Marine Natural Product Research in a Stream from Organic Chemistry to Chemical Biology-
    • Place of Presentation
      Nakhon Si Thammarat, Thailand
    • Year and Date
      2013-02-28
    • Invited
  • [Presentation] 梯子状ポリエーテル類の全合成に有用なテトラヒドロピラン誘導体の効率的合成2012

    • Author(s)
      鳥飼浩平・馬場萌未・中嶋勇晴・山下航・尾上久晃・大石徹
    • Organizer
      第3回統合物質シンポジウム「新エネルギーと物質創製」
    • Place of Presentation
      福岡
    • Year and Date
      2012-06-01
  • [Remarks] アウトリーチ活動(高等学校及び企業向け講演会):Kohei Torikai, Seminar in OP Biofactory, "Role of Synthetic Organic Chemistry in the Research of Natural Products and Drug Discovery" 15th October, 2013, OP Biofactory, Co. Ltd., Uruma, Okinawa.

  • [Remarks] アウトリーチ活動(高等学校及び企業向け講演会):鳥飼浩平,大分東明高等学校講演会,第一部「理系進学からこれまで」,第二部「海洋天然毒を最新有機化学で攻略」,2012年6月20日,大分.

  • [Remarks] ホームページ

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/faculty2_j.cgi?ID=K003874

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Published: 2015-06-25  

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