2012 Fiscal Year Final Research Report
Dual Tissue Marker for Laparoscopic Treatment Navigation
| Project/Area Number |
23750078
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Analytical chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TOYOTA Taro 東京大学, 大学院・総合文化研究科, 准教授 (80422377)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 組織マーカー / 近赤外蛍光イメージング / X 線 CT / ジャイアントベシクル / 内視鏡 |
|---|
| Research Abstract |
The aim of this study is to develop a tissue marker for laparoscopic treatment navigation. We focused on using two types of electromagnetic waves, that is, near infrared light and X ray, for imaging the marker. X-ray imaging, such as X-ray computed tomography (X-ray CT), is already available in hospitals and clinics. Near infrared fluorescence imaging has drawn much attention because the imaging apparatus is not huge and has potential to be installed into endoscopy devices. For both X-ray CT and near infrared fluorescence imaging, we prepared lipid aggregates which have several compartments, encapsulating an X-ray adsorption agent (lipiodolR) and a near infrared fluorescent probe (indocyanine green), by using amphiphilic food additives. We observed the lipid aggregate which was injected into the inner muscle of a pig stomach through a capillary equipped with the endoscopic device under X-ray CT and near infrared fluorescence imaging apparatus and the spot of the lipid aggregate was not blurred in the range of the diameter of 21-31 mm.
|
