2012 Fiscal Year Final Research Report
Quantitative imaging probe for hypoxia
| Project/Area Number |
23750081
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | The University of Tokyo (2012)
Kyoto University (2011) |
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Principal Investigator |
KOMATSU Hirokazu 東京大学, 大学院・薬学系研究科, 特任研究員 (10407140)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 蛍光 / りん光 / 分子プローブ / イメージング / 低酸素 / レシオ測定 / がん / ルテ ニウム錯体 |
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| Research Abstract |
To diagnose cancer in earlier stage, valid imaging method is required. Hypoxia is the indicator for solid cancer. Thus, I focused on develop ‘quantitative’ imaging probe for hypoxia. Developed novel hypoxia probe showed ratiometric and reversible response to O2, successfully applied to in cell and in vivo imaging of hypoxia.
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