2012 Fiscal Year Final Research Report
Development of a novel method for highly accurate and precise LC-MSanalysis: introduction of separation-oriented derivatization method
| Project/Area Number |
23750092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | クロマトグラフィー / 質量分析 |
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| Research Abstract |
A separation-oriented derivatization method for highly accurate and precise LC-MS/MS analysis of target analytes has been developed utilizing affinity of perfluoroalkyl group and one another, namely fluorous. In this method, the matrix-induced effects during LC-MS analysis could be eliminated because the perfluoroalkylated analytes could be retained specifically on a perfluoroalkyl-modified LC column, whereas non-fluorous endogenous matrix components were poorly retained under the separation conditions.
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Research Products
(36 results)
