2012 Fiscal Year Final Research Report
Control of cellular microenvironments and analysis of cellular functions by using caged culture substrates
| Project/Area Number |
23750093
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
NAKANISHI Jun 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 独立研究者 (60360608)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体分析 |
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| Research Abstract |
Dynamic substrates that change surface cell adhesiveness in response to an extracellular stimulus are useful for fundamental biological studies as well as tissue engineering applications. This project focused on the development and applications of photo-responsive “caged culture substrates”. By functionalization of a surface with the controlled amino group density, we succeeded in improving the photoswitching efficiency. Furthermore, by analyzing cell migration in controlled cellular microenvironments, we found that the cells achieve collective characteristics as increasing cluster size as well as incubation time.
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