2012 Fiscal Year Final Research Report
Development of Novel Carbon-Carbon Bond Forming Reactions for Application to Industrial Process
| Project/Area Number |
23750104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
AIKAWA Kousuke 東京工業大学, 大学院・理工学研究科, 助教 (30401532)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 不斉合成 / 反応 / 炭素-炭素結合生成反応 |
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| Research Abstract |
I have succeeded in highly enantioselective and atom-economical reactions, especially [2 + 2] cycloaddition of diverse array of alkynes with trifluoropyruvate using chiral dicationic BINAP-Pd catalyst to provide the unprecedentedly stable oxetene derivatives. The reaction takes place with good-to-excellent yields and various substituents on the internal alkynes. This catalytic process offers not only the first synthetic method of stable oxetene derivatives but also new entry to oxetenes as a novel chiral trifluoromethyl building block for pharmaceuticals and agrochemicals.
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