2012 Fiscal Year Final Research Report
Design and Synthesis of Octahedral Metal Complexes with Linear Multidentate Ligands
| Project/Area Number |
23750108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 触媒設計 / 反応 |
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| Research Abstract |
Asymmetric catalysis converts a prochiral substrate into an enantiomericallyenriched chiral product. The enantioselectivity has generally been interpreted as a result of competing diastereomorphic catalytic cycles involving a single chiral catalyst. We have designed and synthesized Ph-BINAN-H-Py which is characterized by i) inside sp^N/outside sp^N, ii) donor-acceptor bifunctional ability, and iii) cis-alpha-selective formation of octahedral metal complexes. The utility of ligands has been demonstrated in asymmetric hydrogenation of aromatic ketones in combination with a Ru-π-allyl precursor. A series of detailed mechanistic studies should stimulate our ideas for development of asymmetric molecular catalysis.
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