2012 Fiscal Year Final Research Report
Hydration of organic compounds catalyzed by metal porphyrins
| Project/Area Number |
23750109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
NAKA Hiroshi 名古屋大学, 物質科学国際研究センター, 助教 (70431517)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 錯体 / 有機金属触媒 / 反応有機化学 / 水和反応 / ポルフィリン / 分子触媒 |
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| Research Abstract |
We have developed water-soluble cobalt(III) porphyrin complexes that promote the hydration of terminal alkynes to produce methyl ketones. The alkyne hydration was compatible with the presence of acid/base- or redox-sensitive functional groups such as alkyl silyl ethers; allyl ethers; trityl ethers; benzyl ethers; carboxylic esters; boronic esters; carboxamides; nitriles; and acetal groups. Some of the alkyne substrates tested here are otherwise difficult to hydrate. The reaction mechanism was also clarified using spectroscopic, kinetic, and theoretical methods.
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