2012 Fiscal Year Final Research Report
Catalytic Asymmetric Synthesis of Chiral Fluorinated Molecules
| Project/Area Number |
23750111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 有機合成 / フッ素化学 / 不斉合成 |
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| Research Abstract |
Introduction of a trifluoromethyl group into biologically active compounds often modifies their physical and/or biological properties. Here, we have succeeded in the enantioselective Diels-Alder reaction of β-trifluoromethylacrylates to give corresponding cyclohexenes having a trifluoromethyl group at the chiral carbon center. We also demonstrated the organocatalytic asymmetric 1,4-addition of 4,4,4-trifluorocrotonaldehyde.The resulting adducts could be converted into potential synthetic intermediates for new drug candidates.
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