2012 Fiscal Year Final Research Report
Development of Introducing Method of Hetero-functional groups to Alkenes via Anti-Markovnikov Nucleophilic Attack as a Key Step
| Project/Area Number |
23750112
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nara Women's University |
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Principal Investigator |
URA Yasuyuki 奈良女子大学, 自然科学系, 准教授 (40335196)
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| Project Period (FY) |
2011 – 2012
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| Keywords | パラジウム錯体 / ワッカー型酸化 / 逆マルコフニコフ求核攻撃 / 末端アルケン / ピナコール / キノン / 分子状酸素 |
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| Research Abstract |
We developed a synthetic method for terminal acetals from terminal alkenes and pinacol, and environmental load-reducing synthetic methods for aldehydes from terminal alkenes under mild reaction conditions. In these reactions, control of the regioselectivity of nucleophilic attack to coordinated alkenes is the key. By using bulky oxygen nucleophiles, the selectivity was successfully controlled to anti-Markovnikov manner.
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