2012 Fiscal Year Final Research Report
The development of the catalytic generation of radical species with iron reagents and its synthetic applications
| Project/Area Number |
23750114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 鉄 / ラジカル / カップリング / ビアリール / ヘテロ芳香族化合物 / カルコゲン / フェノール / 芳香族ボロン酸 |
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| Research Abstract |
We found that iron reagents like FeCl3was effective mediator in the direct calcogenation of phenols, in which a diverse set of calcogenated phenol derivatives were obtained in regioselective manner. In addition, we have also developed that the iron/oxidant system was greatly effective for the generation of aryl radicals from the reaction with aryl boronic acids. The protocol was applied to the direct arylation of quinones and heteroarenes, giving rise to regio- and chemo-selective arylated products in good yields.
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