2012 Fiscal Year Final Research Report
Successive construction of cyclic skeletons via migration of transition metals
| Project/Area Number |
23750115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 選択的合成・反応 / 錯体・有機金属触媒 / 遷移金属触媒反応 / 炭素-水素結合切断 / 炭素-炭素結合切断 / 1,4-ロジウム移動 / 環状骨格構築 / 連続的結合生成 |
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| Research Abstract |
1,4-Migration of transition metals is a useful synthetic tool for intramolecular activation of neighboring C-H bonds and has been exploited in the construction of complex organic frameworks. In this study, research on transition-metal-catalyzed reactions involving 1,4-rhodium migration was conducted, and three reactions giving cyclic skeletons were developed. In particular, indanes and spirobiindanes were synthesized by rhodium-catalyzed arylation using arylboron compounds.
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