2013 Fiscal Year Final Research Report
Molecular-targeted nanobubbles for ultrasound contrast agents using a newly synthesized surfactant
| Project/Area Number |
23750168
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional materials chemistry
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
TSUCHIYA Koji 東京理科大学, 理学部, 助教 (50398822)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | ナノバブル / 超音波診断 / 造影剤 / 分子認識 / シクロアミロース修飾界面活性剤 / リン脂質 |
|---|
| Research Abstract |
The present study aims to develop molecular-targeted ultrasound contrast agents (nanobubbles) using a newly synthesized cycloamylose-modified surfactant (CA-LA). Nanobubbles with high dispersion stability in blood serum can be obtained using mixed CA-LA and a polyethylene glycol (PEG)-modified phospholipid as the dispersion agents. The labeling of folic acid to the nanobubbles enhances their accumulation to KB cells having folate receptors. Galactose-labeled nanobubbles are selectively accumulated to human liver tumor cells (HepG2), in which asialoglycoprotein receptors are generated. The results reveal that the nanobubbles obtained in the present study can be a useful ultrasound contrast agent having high stability in blood and high accumulation ability to tumor cells.
|
