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2012 Fiscal Year Final Research Report

Activation of target genes with crosslink-forming oligonucleotide

Research Project

  • PDF
Project/Area Number 23750180
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemistry related to living body
Research InstitutionTohoku University

Principal Investigator

HAGIHARA Shinya  東北大学, 多元物質科学研究所, 助教 (80373348)

Project Period (FY) 2011 – 2012
Keywords核酸関連化学
Research Abstract

Crosslink forming oligonucleotide (CFO) was used for target gene specific Inhibition of microRNA (miRNA) functions. The method can interfere with specific miRNA-mRNA interactions by recognizing the sequences unique to the 3'-UTR that are inherent in each mRNAs.

  • Research Products

    (5 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Production of truncated protein by the crosslink formation of mRNA with2'-OMe oligoribonucleotide containing2-amino-6-vinylpurine

    • Author(s)
      Shinya Hagihara, Shuhei Kusano, Wei-Chen Lin, Xiao-guang Chao, Tsuneaki Hori, Shuhei Imoto, Fumi Nagatsugi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 22 Pages: 3870-3872

    • DOI

      DOI:10.1016/j.bmcl.2012.04.123

    • Peer Reviewed
  • [Presentation] 架橋性オリゴ核酸を用いた細胞内遺伝子発現制御2013

    • Author(s)
      萩原伸也、草野修平、井田裕太、岩本直生、永次史
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Year and Date
      2013-03-25
  • [Presentation] 立体配座を固定化した新規架橋性分 子の開発2013

    • Author(s)
      井田裕太、草野修平、岩本直生、萩原伸也、永次史
    • Organizer
      日本化学会第93春季年会
    • Place of Presentation
      立命館大学
    • Year and Date
      2013-03-25
  • [Presentation] 機能性オリゴ核酸のRNAへの架橋形成による遺伝子発現制御2012

    • Author(s)
      萩原伸也、草野修平、鈔暁光、岩本直生、永次史
    • Organizer
      第92日本化学会春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2012-03-26
  • [Presentation] 2'-OMe RNA containing 2-amino-6-vinylpurine as a potent gene regulator2011

    • Author(s)
      萩原伸也、井本修平、鈔暁光、堀恒晃、草野修平、永次史
    • Organizer
      第38際核酸化学シンポウム
    • Place of Presentation
      札幌
    • Year and Date
      2011-11-09

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Published: 2014-09-25  

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