2012 Fiscal Year Final Research Report
Coordination chemistry to clinical applications-development of MRI probes based on redox chemistry of metal complexes
| Project/Area Number |
23750195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子プローブ / MRI / イメージング / 低酸素微小環境 |
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| Research Abstract |
The purpose of this project is to develop new MRI imaging probes that enable non-invasive visualization of hypoxic region in tumor. To this end, we tried to create hypoxia cleavable linker molecules by taking advantages of the redox activity and ligand exchanging property of a cobalt complex. Moreover, the hypoxia-selective linker was combined with a gadlinium complex or a fluorine-containing compound to achieve hypoxia-selective MRI contract agents.
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Research Products
(5 results)
