2013 Fiscal Year Final Research Report
Synthesis and characterization of layered double hydroxide nanosphere and its application for novel drug delivery material
| Project/Area Number |
23750233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic industrial materials
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| Research Institution | Iwate University |
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Principal Investigator |
AISAWA Sumio 岩手大学, 工学研究科, 助教 (40333752)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 層状・層間化合物 / ドラッグデリバリーシステム / 抗がん剤 / カーボンナノスフィア / 細胞毒性 |
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| Research Abstract |
Layered double hydroxide (LDH) has been considerable attentions as materials for drug delivery in pharmaceutical field. In this study, the synthesis of LDH nanosphere (LDH-NS) by using carbon nanosphere template and the intercalation of anticancer drug, 5-fluorouracil (5-FU), into the LDH-NS by the reconstruction method have been investigated in order to promote the cellular uptake of 5-FU. The XRD patterns of the 5-FU/LDH-NS showed that the interlayer distance was expanded with the intercalation of 5-FU. The results of HeLa cytotoxicity assay indicated that the 5-FU/LDH-NS performed well cytostatic effect, which is three times higher than that of 5-FU.
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