2012 Fiscal Year Final Research Report
Enzymatic oxidation reactions using clustered liposomes that specifically response to shear flow and temperature change
| Project/Area Number |
23760751
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biofunction/Bioprocess
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
YOSHIMOTO Makoto 山口大学, 大学院・医学系研究科, 准教授 (80322246)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | リポソーム / 酵素反応 / バイオリアクター / ナノバイオ / せん断流 |
|---|
| Research Abstract |
The membrane properties of closed phospholipid bilayers (liposomes) could be altered by relatively small changes in temperature and shear stress generated by the flow and mixing conditions in bioreactors. These membrane properties of liposomes were regulated based on their composition, size and clustering characteristics. Based on the results obtained, the catalytic oxidation reaction systems, where the stability and reactivity of enzymes could be widely regulated, were developed using various types of enzyme-containing liposomes suspended in a bioreactor.
|
