2012 Fiscal Year Final Research Report
Development of capillary-like network for creating three-dimensional tissues
| Project/Area Number |
23760752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kagoshima University (2012)
Kyushu University (2011) |
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Principal Investigator |
TAKEI Takayuki 鹿児島大学, 大学院・理工学研究科, 准教授 (90468059)
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| Project Period (FY) |
2011 – 2012
|
| Keywords | 毛細血管 / 毛細血管 / ヒドロゲル / ファイバー |
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| Research Abstract |
Poly(methyl methacrylate)(PMMA)microfibers of approximately 10μm in diameter were prepared using wet spinning technique. The microfibers were embedded in agarose gel and dissolved specifically, resulting in formation of capillary-like network in the gel. The gel was freeze-dried and hepatoblastomawas seeded into the sponge-like gel. Then, the sponge was coated with agarose gel. Culture medium was perfused into the capillary-like network in the sponge. Albumin productivity of the sponge with perfusion of medium was higher than that without medium perfusion.
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Research Products
(4 results)
