2012 Fiscal Year Final Research Report
Development of oral immunotherapy for allergies using TGF-betacontaining egg white derived from transgenic avian
| Project/Area Number |
23760753
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 遺伝子導入ニワトリ / アレルギー治療 / スギ花粉症 / 腸管免疫寛容 / アレルギー抑制性サイトカイン / エピトープペプチド / 経口ワクチン |
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| Research Abstract |
Here, we attempted to generate genetically manipulated chickens producing human T -cell epitopes derived from Japanese cedar pollen and anti-allergic cytokine, TGF-ss in order to develop a treatment fro pollen allergy by inducing oral tolerance. The number of sneezing and the allergen-specific IgE level were significantly decreased in allergic mice fed with T-cell epitope-containing egg white. GM chickens harboring TGF-ssgene were generated using oviduct-specific expression system. GM chicken model will extend the usage of therapeutic proteins in eggs, which may serve as edible pharmaceuticals for allergy immunotherapy based on oral tolerance.
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