2013 Fiscal Year Final Research Report
Chemical biology approach to ganglioside-induced amyloidosis
| Project/Area Number |
23760758
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SAKONO MASAFUMI 独立行政法人理化学研究所, 伊藤細胞制御化学研究室, 客員研究員 (50391959)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ガングリオシド / アミロイド / アミロイドベータ / 糖鎖生物学 / 脂質ラフト |
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| Research Abstract |
Amyloid beta which is causative agent of Alzheimer's disease is widely known to form aggregate nucleation by binding with ganglioside GM1, and this nucleation is suggested to enhance aggregation of amyloid beta in vivo. In this study, the synthesis of non-native form ganglioside based on GM1 structure was investigated to clarify the interaction between ganglioside and amyloid beta. We examined synthesis pathway of GM1-type glycan which possess reactive site by click chemistry, and obtained optimal synthesis method.
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