Investigations on Radiobiological effects induced by high dose rate irradiation with laser-accelerated protons.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23760831
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nuclear engineering
• Research Institution: Japan Atomic Energy Agency
• Principal Investigator: YOGO Akifumi 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究副主幹 (50421441)
• Project Period (FY): 2011 – 2012
• Keywords: 放射線工学 / ビーム科学 / レーザー駆動粒子線

Research Abstract

Recently, high-intensity laser ion acceleration has been suggested as a potential, cost-saving alternative technology to conventional accelerators for radiotherapy. In this work, investigations of the biological effects of the high bunch current and short bunch duration, that are typical of laser-acceleration, are reported. The radiobiological effects of high dose-rate irradiation with laser-driven proton beams are compared with those of beams derived from conventional ion accelerators.

Research Products

• [Journal Article] レーザー駆動陽子線の生物照射効果(勧誘論文) (2012)
  • Author(s): 余語覚文
  • Journal Title: レーザー学会誌「レーザー研究」 Volume: 40 Pages: 842
  • Peer Reviewed
• [Journal Article] レーザー駆動陽子線の生物実験への応用 (2012)
  • Author(s): 余語覚文
  • Journal Title: J. Plasma Fusion Res. Volume: 88 Pages: 21-24
  • Peer Reviewed
• [Journal Article] Measurement of DNA Double-Strand Break Yield in Human Cancer Cells by High Current, Short Duration Bunches of Laser-Accelerated Protons (2011)
  • Author(s): Akifumi Yogo, Katsutoshi Sato, Masaharu Nishikino, Takuya Maeda, Hironao Sakaki, Toshihiko Hori, Koichi Ogura, Mamiko Nishiuchi, Teruki Teshima, Hiroaki Nishimura, Kiminori Kondo, Paul R. Bolton, and Shunichi Kawanishi
  • Journal Title: Jpn. J. Appl. Phys. Volume: 50 Pages: 106401
  • Peer Reviewed
• [Presentation] レーザー駆動イオン加速のための10TW級高コントラストレーザーの開発 (2013)
  • Author(s): 余語覚文, 他
  • Organizer: レーザー学会学術講演会 第33回年次大会
  • Place of Presentation: 姫路市
  • Year and Date: 20130100
• [Presentation] Radiobiology with Laser-accelerated Proton Beams (2012)
  • Author(s): A. Yogo, et al.
  • Organizer: ICACS International Conference on "Atomic Collisions in Solids "-25
  • Place of Presentation: Kyoto, JAPAN
  • Year and Date: 20121021-25
• [Presentation] レーザー駆動イオン加速とその生物応用研究 (2012)
  • Author(s): 余語覚文, 他
  • Organizer: 日本物理学会第67回年次大会 若手奨励賞受賞講演
  • Place of Presentation: 関西学院大学
  • Year and Date: 20120300
• [Presentation] 精密に時間制御された高強度レーザーによるイオン加速 (2012)
  • Author(s): 余語覚文
  • Organizer: レーザー学会学術講演会第32回年次大会、レーザー学会業績賞受賞記念講演
  • Place of Presentation: TKP 仙台カンファレンスセンタ
  • Year and Date: 20120100
• [Presentation] レーザー駆動陽子線によるヒトがん細胞生存率RBE 測定 (2011)
  • Author(s): 余語覚文, 他
  • Organizer: 日本原子力学会 2011 年秋の大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 20110900
• [Presentation] Radiobiology with laser-accelerated ion beams: Application of the quasi -monoenergetic proton (2011)
  • Author(s): A. Yogo, et al.
  • Organizer: The 3rd International Symposium on Laser-driven relativistic plasmas applied for science, industry and medicine
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20110601-03
• [Presentation] Radiobiology with laser accelerated quasi -monoenergetic proton beams (2011)
  • Author(s): A. Yogo, et al.
  • Organizer: SPIE Optics + Optoelectronics 2011
  • Place of Presentation: Czech Republic
  • Year and Date: 20110418-21
• [Patent(Industrial Property Rights)] レーザー装置用ビームライン、レーザー装置 (2013)
  • Inventor(s): 余語覚文、近藤公伯
  • Industrial Property Rights Holder: 独立行政法人日本原子力研究開発機構
  • Industrial Property Number: 発明,特許2013-005131
  • Filing Date: 2013-01-16