2012 Fiscal Year Final Research Report
Spatial regulation mechanism of initiation of meiotic recombination
| Project/Area Number |
23770003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUGOU Kazuto 東京大学, 大学院・総合文化研究科, 特任研究員 (60554425)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 減数分裂 / 相同組換え / 染色体高次構造 |
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| Research Abstract |
Meiosis is a special type of cell division for sexual reproduction and produces gametes.Genetic recombination between homologous chromosomes is required for meiosis. A defect in the recombination results in declining biodiversity and disorders caused by chromosomal abnormality. Meiotic chromosomes interact with various proteins. Theinteraction dynamically alters chromosome structure. In this study, we analyzed an initiation mechanism of meiotic recombination by a chromosomal structural protein using genome-wide analyses and bioinformatics.
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