2012 Fiscal Year Final Research Report
The role of host factors in LINE retrotransposition
| Project/Area Number |
23770004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KAJIKAWA Masaki 東京工業大学, 大学院・生命理工学研究科, 講師 (90361766)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ゲノム構築 / 再編 / 維持 / 転移因子 |
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| Research Abstract |
Transposable elements, including LINEs, are major components of eukaryotic genomes. They mobilize and amplify their own copies via the reverse transcription of their own RNA. This mobilization mechanism is called retrotransposition, and it requires proteins encoded by transposable elements. However, retrotransposition is not completed by the proteins only, and host encoded proteins are most likely required for retrotransposition. This study found that a retrotransposition intermediate of LINEs contains a large amount of host encoded proteins, which probably participate in retrotransposition.
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