2012 Fiscal Year Final Research Report
Sensing mechanism of lipid asymmetry and cellular response
| Project/Area Number |
23770135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
OBARA Keisuke 北海道大学, 大学院・薬学研究院, 助教 (30419858)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞膜 / 脂質 / タンパク質 / 脂質非対称 / センサー / 細胞情報伝達機構 |
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| Research Abstract |
In the plasma membrane, lipid composition differs between the outerand inner leaflet. Maintenance and proper alteration in such lipid asymmetry is essential for cellviability. In this work, we identified a sensor protein, Rim21, which detects alteration in lipidasymmetry, embodying a novel concept that cells monitor the status of lipid asymmetry. We alsofound a novel factor, Opt2, which is induced as a downstream event of Rim21, and is considered toact in mending of disturbed lipid asymmetry.
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