2012 Fiscal Year Final Research Report
Analysis of interactions among transmembrane proteins required for activation of the yeast HOG MAPK pathway in response to osmotic stress
| Project/Area Number |
23770140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞情報伝達機構 |
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| Research Abstract |
Transmembrane (TM) interactions between the tetra-spanning membrane protein Sho1 and the single-path membrane protein Opy2, and the cytoplasmic domain of the osmosensor Hkr1, are required for activation of the Hog1 MAPK via the Hkr1 dependent SHO1 branch pathway in response to osmotic stress. The extracellular cysteine-rich (CR) region of Opy2 is required for interaction with Hkr1/Msb2.
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