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2012 Fiscal Year Final Research Report

ER redox regulation by ER GSH transporter

Research Project

  • PDF
Project/Area Number 23770158
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional biochemistry
Research InstitutionKyoto University

Principal Investigator

HOSEKI Jun  京都大学, 生理化学研究ユニット, 特定准教授 (40423058)

Project Period (FY) 2011 – 2012
Keywordsレドックス / 小胞体
Research Abstract

Glutathione is required for ER redox regulation. GSH is synthesized in cytosol while the mechanism by which GSH is transported into the ER is still unknown. We showed that ER membrane proteins are necessary for GSH transport into the ER and identified inhibitors for GSH transport into the ER by a sensitive detection system using roGFP for GSH transport into the ER.

  • Research Products

    (16 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results) Book (2 results) Remarks (1 results)

  • [Journal Article] A fluorescence resonance energy transfer (FRET)-based redox sensor reveals physiological role of thioredoxin in the yeast Saccharomyces cerevisiae2013

    • Author(s)
      奥 公秀、寳関 淳、市来弥生、阪井康能
    • Journal Title

      FEBS Letter

      Volume: 587巻 Pages: 793-798

    • DOI

      DOI:10.1016/j.febslet.2013.02.003

    • Peer Reviewed
  • [Journal Article] Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj52011

    • Author(s)
      萩原誠智、前川憲一、鈴木 守、潮田 亮、新木和孝、松本悠史、寳関 淳、永田和宏、稲葉謙次
    • Journal Title

      Molecular Cell

      Volume: 41巻 Pages: 432-444

    • DOI

      DOI:10.1016/j.molcel.2011.01.021

    • Peer Reviewed
  • [Presentation] 酵母Saccharomyces ceruvisiaeにおけるペルオキシソーム内レドックス制御因子の解析2013

    • Author(s)
      島並祐子、奥 公秀、寳関 淳、阪井康能
    • Organizer
      日本農芸化学会関西支部第478回講演会
    • Place of Presentation
      京都市
    • Year and Date
      2013-02-02
  • [Presentation] Involvement in mitochondrial function by antioxidants protects cellular oxidation caused by proteasome inhibiton2013

    • Author(s)
      Maharjan Sunita、寳関 淳、奥 公秀、阪井康能
    • Organizer
      日本農芸化学会関西支部第478回講演会
    • Place of Presentation
      京都市
    • Year and Date
      2013-02-02
  • [Presentation] Glycosylation-independent ERAD pathway serves as a backup system under ER stress2012

    • Author(s)
      潮田 亮、寳関 淳、永田和宏
    • Organizer
      EMBO/EMBL Symposium "Quality Control-From Molecules to Organelles"
    • Place of Presentation
      Germany
    • Year and Date
      20120919-22
  • [Presentation] Reduction mechanism of a disulfide reductase, ERdj5 in the oxidative redox environment of the ER2012

    • Author(s)
      寳関 淳、阪井康能、永田和宏
    • Organizer
      Gordon Research Conferences: Thiol-Based Redox Regulation& Signaling
    • Place of Presentation
      USA
    • Year and Date
      20120729-0803
  • [Presentation] Glycosylation-Independent ERAD pathway serves as a backup system under ER stress2012

    • Author(s)
      潮田 亮、寳関 淳、永田和宏
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会ワークショップ
    • Place of Presentation
      神戸市
    • Year and Date
      20120528-31
  • [Presentation] Biochemical characterisation of Pfj2, a Plasmodium falciparum heat shock protein 40 chaperone potentially involved in protein quality control in the endoplasmic reticulum2012

    • Author(s)
      Omolola Afolayan、Eva-Rachele Pesce、寳関 淳、平山尚志郎、永田和宏、Caroline Knox、Gregory L. Blatch
    • Organizer
      South African Society for Biochemistry and Molecular Biology/Federation of African Societies of Biochemistry and Molecular Biology SASBMB/FASBMB Congress 2012
    • Place of Presentation
      South Africa
    • Year and Date
      20120129-0201
  • [Presentation] レドックス制御とタンパク質品質管理2012

    • Author(s)
      寳関 淳
    • Organizer
      京都大学学際融合教育研究推進センター 生理化学研究ユニット 第2回シンポジウム
    • Place of Presentation
      京都市
    • Year and Date
      2012-06-13
  • [Presentation] 細胞内レドックス状態の可視化とこれを利用したレドックスモジュレーターの探索2012

    • Author(s)
      寳関 淳、阪井康能
    • Organizer
      疾病予防・食品機能開発評価システムに関するフォーラム
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-13
  • [Presentation] Non-glycoprotein ERAD pathway serves as a backup system under ER stress2011

    • Author(s)
      潮田 亮、寳関 淳、永田和宏
    • Organizer
      Cold Spring Harbor Asia Conference, "Protein Homeostasis in Health & Disease"
    • Place of Presentation
      China
    • Year and Date
      20110926-30
  • [Presentation] 糖たんぱく質ERADにおけるERdj5の役割/The role of ERdj5 in glycoprotein ERAD pathway2011

    • Author(s)
      萩原誠智、前川憲一、鈴木 守、潮田 亮、新木和孝、松本悠史、寳関 淳、永田和宏、稲葉謙次
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      20110627-29
  • [Presentation] ジスルフィド還元酵素ERdj5 による小胞体関連分解のレドックス制御2011

    • Author(s)
      寳関 淳
    • Organizer
      第84回日本生化学会大会シンポジウム「レドックス反応システムによる細胞制御機構」
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-21
  • [Book] 酵母のレドックス認識機構を応用した新しいセンサータンパク質の開発2013

    • Author(s)
      寳関 淳、奥 公秀、阪井康能
    • Total Pages
      64-69
    • Publisher
      FRAGRANCE JOURNAL
  • [Book] レドックス異常を回復する化合物レドックスモジュレーターの探索:Redoxfluorの創薬への利用2012

    • Author(s)
      阪井康能、寳関 淳、奥 公秀
    • Total Pages
      158-163
    • Publisher
      遺伝子医学MOOK
  • [Remarks] 研究室ホームページ

    • URL

      http://www.seigyo.kais.kyoto-u.ac.jp

URL: 

Published: 2014-09-25  

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