2013 Fiscal Year Final Research Report
Epigenetic regulation of brain-specific O-mannose glycans
| Project/Area Number |
23770163
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KIZUKA Yasuhiko 独立行政法人理化学研究所, 疾患糖鎖研究チーム, 基礎科学特別研究員 (20564743)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糖鎖生物学 / 糖転移酵素 / エピジェネティクス / GnT-IX |
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| Research Abstract |
Aim of this study is to unveil how glycans are expressed in tissue-specific manners. In detail, we focused on a brain-specific glycan, branched O-mannose glycan. As a novel approach, concept and technique of epigenetics were adopted. As a result, expression of GnT-IX that is essential for biosynthesis of O-brain-specific mannose glycans, is epigenetically regulated by post translational modifications of histone.
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