2012 Fiscal Year Final Research Report
Mechanism of translation arrest and degradation of aberrant products in mRNA quality control systems
| Project/Area Number |
23770198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Tohoku University |
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Principal Investigator |
KUROHA Kazushige 東北大学, 大学院・薬学研究科, 研究支援者 (50580015)
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| Project Period (FY) |
2011 – 2012
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| Keywords | mRNA 品質管理 / mRNA 分解 / タンパク質分解 |
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| Research Abstract |
We have analyzed two major of aberrant mRNAs, stop codon-less mRNA and nonsense-containing mRNA, to reveal the mechanism of the aberrant translation recognition and stimulation of aberrant products degradation. We found that mechanism of stop codon-less mRNA degradation by Dom34:Hbs1 complex. We also found that the mis-folded conformation of PTC products is important for leading to its degradation by Upf factors.
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