2013 Fiscal Year Final Research Report
The roles of Lys63-typed polyubiqitination in cellular signal transduction and carcinogenesis
| Project/Area Number |
23770203
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOHDA Jin 東京大学, 医科学研究所, 特任講師 (90361617)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ユビキチン / 細胞内シグナル伝達 / 発癌 / 自然免疫応答 / 翻訳後修飾 |
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| Research Abstract |
Polyubiquitination is the formation of an ubiquitin chain by the binding of ubiquitin molecules to a target protein. Polyubiquitin chains linked through different Lysine residues have different functions in the target proteins. In this study, I developed the method for purification of Lys63 (K63)-linked polyubiquitinated proteins from cell lysate. Furthermore, I demonstrated that K63-linked polyubiquitination is involved in the development of adult T-cell leukemia (ATL), which is caused by infection with HTLV-1, through regulation of NF-kB activation by viral protein, Tax.
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