2012 Fiscal Year Final Research Report
Analysis of maturation process of endo -siRNA precursor
| Project/Area Number |
23770210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Niigata University |
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Principal Investigator |
MIYOSHI Tomohiro 新潟大学, 研究推進機構超域学術院, 助教 (60534550)
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| Project Period (FY) |
2011 – 2012
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| Keywords | RNA |
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| Research Abstract |
Non-coding small RNAs act as functional molecules in cells. Endogenous siRNA (endo-siRNA) isone of the small RNAs, but its biosynthesis process is unknown. In this study, we succeeded indetection of endo-siRNA precursor present in the cell. Further, we showed that novel cytoplasmic fociare functionally important in the endo-siRNA biosynthesis. Furthermore, we identified novel proteinrelated to the biosynthesis mechanism of endo-siRNA.
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