2012 Fiscal Year Final Research Report
Molecular mechanism of the signaling involved in nutrient sensing and cell regulation that mediated by TORC1 in fission yeast
| Project/Area Number |
23770229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
NAKASHIMA Akio 神戸大学, 自然科学系先端融合研究環, バイオシグナル研究センター (70397818)
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| Project Period (FY) |
2011 – 2012
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| Keywords | シグナル伝達 / TOR / 栄養応答 / 細胞機能制御 / 分裂酵母 |
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| Research Abstract |
The TORC1 signaling plays a crucial role in a large number of cellular processes in response to nutrient signals. In this study, we investigated molecular mechanism of the nutrient-dependent TORC1 signaling in the fission yeast Schizosaccharomyces pombeand demonstrated three protein kinases as its substrates. Of these, it was especially revealed how Psk1 is regulated by TORC1 responding to nutrient availability. The findings obtained from this study indicate a milestone to elucidate the universal mechanism of cellular regulation by TORC1 signaling among eukaryotes.
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[Journal Article] Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes2013
Author(s)
Nakashima A, Kawanishi I, Eguchi S, Yu EH, Eguchi S, Oshiro N, Yoshino K, Kikkawa U, Yonezawa K.
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Journal Title
Journal of Biomedical Science
Volume: 20
Pages: 24
DOI
Peer Reviewed
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